61+ научни статии за вредите от ваксината срещу човешки папилома вирус (HPV)

61 научни статии за вредите от ваксината срещу човешки папилома вирус (HPV), взети от фейсбук групата на д-р Тенпени.

1. Demyelinating disease and vaccination of the human papillomavirus. Álvarez-Soria MJ, Hernández-González A, Carrasco-García de León S, del Real-Francia MÁ, Gallardo-Alcañiz MJ, López-Gómez JL. Rev Neurol, 2011, 52, 472. http://www.ncbi.nlm.nih.gov/pubmed/21425100

2. Demyelinating disease and polyvalent human papilloma virus vaccination. Chang J, Campagnolo D, Vollmer TL, Bomprezzi R. J Neurol Neurosurg Psychiatry. 2011 Nov;82(11):1296-8.https://www.ncbi.nlm.nih.gov/pubmed/20935322

3. Human papilloma virus vaccine and primary ovarian failure: another facet of the autoimmune/inflammatory syndrome induced by adjuvants. Colafrancesco S, Perricone C, Tomljenovic L, Shoenfeld Y. Am. J Reprod Immunol, 2013, 70, 309. http://www.ncbi.nlm.nih.gov/pubmed/23902317

4. Pancreatitis following human papillomavirus vaccination. Das A, Chang D, Biankin AV, Merrett ND. Med J Aust, 2008, 189, 178.http://www.ncbi.nlm.nih.gov/pubmed/18673112

5. Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl. Della Corte C, Carlucci A, Francalanci P, Alisi A, Nobili V. Vaccine, 2011, 29, 4654.
http://www.ncbi.nlm.nih.gov/pubmed/21596082

6. A 16-Year-Old Girl With Bilateral Visual Loss and Left Hemiparesis Following an Immunization Against Human Papilloma Virus. DiMari J Jr, Hajjar M, Ciesielski T. J Child Neurol, 2010, 25, 321.http://www.ncbi.nlm.nih.gov/pubmed/20189933

7. Human papillomavirus vaccine and systemic lupus erythematosus, Gatto M, Agmon-Levin N, Soriano A, Manna R, Maoz-Segal R, Kivity S, Doria A, Shoenfeld Y. Clinical Rheumatology, 2013, 32, 1301.http://www.ncbi.nlm.nih.gov/pubmed/23624585

8. Premature ovarian failure 3 years after menarche in a 16-year-old girl following human papillomavirus vaccination. Little DT, Ward HRG. BMJ Case Rep, 2012, bcr2012006879.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543769/

9. Vasculitis following HPV immunization. Melo Gomes S, Glover M, Malone M, Brogan P. Rheumatology, 2013, 52, 581.https://www.ncbi.nlm.nih.gov/pubmed/22879461

10. Acute disseminated encephalomyelitis with tumefactive lesions after vaccination against human papillomavirus. Mendoza Plasencia Z, Gonzalez Lopez M, Fernandez Sanfi el ML, Muniz Montes JR. Neurologia, 2010, 25, 58. http://www.ncbi.nlm.nih.gov/pubmed/20388462

11. Bilateral Papilledema Following Human Papillomavirus Vaccination. Marco Rossia, Chiara Bettini, Caterina Paganoc. J Med Cases, 2011, 2, 222. http://www.journalmc.org/index.php/JMC/article/view/256

12. Immune thrombocytopenic purpura following human papillomavirus vaccination. Pugnet G, Ysebaert L, Bagheri H, Montastruc JL, Laurent G. Vaccine, 2009, 27, 3690.
http://www.ncbi.nlm.nih.gov/pubmed/19464550

13. HPV vaccine: a cornerstone of female health a possible cause of ADEM. V. Schaffer, S. Wimmer, I. Rotaru, R.Topakian, H . P. Haring, F. T. Aichner. J Neurol 2008, 255, 1818.
https://www.ncbi.nlm.nih.gov/pubmed/?term=18491173

14. CNS demyelination and quadrivalent HPV vaccination. Sutton I, Lahoria R, Tan I, Clouston P, Barnett M. Mult Scler. 2009, 15, 116.http://www.ncbi.nlm.nih.gov/pubmed/18805844

15. Acute disseminated encephalomyelitis following vaccination against human papilloma virus. Wildemann B, Jarius S, Hartmann M, Regula JU, Hametner C. Neurology, 2009, 72, 2132.
http://www.neurology.org/content/72/24/2132.extract

16. Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants”: Case Report and Literature Review. Tomljenovic L, Colafrancesco S, Perricone C, Shoenfeld Y. Journal of Investigative Medicine High Impact Case Reports, 2014, 2(1), 1.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528866/

17. Postural tachycardia syndrome following human papillomavirus vaccination. S. Blitshteyn. European Journal of Neurology, 2014, 21, 135http://www.ncbi.nlm.nih.gov/pubmed/24102827

18. Peripheral sympathetic nerve dysfunction in adolescent Japanese girls following immunization with the human papillomavirus vaccine. Kinoshita T, Abe RT, Hineno A, Tsunekawa K, Nakane S, Ikeda S. Intern Med, 2014, 53(19), 2185. http://www.ncbi.nlm.nih.gov/pubmed/25274229

19. Suspected side effects to the quadrivalent human papilloma vaccine. Brinth L, Theibel AC, Pors K, Mehlsen J. Dan Med J, 2015, 62(4), A5064.https://www.ncbi.nlm.nih.gov/pubmed/25872549

20. Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old .girl .Della Corte Ca, Carlucci A, Francalanci P, Alisi A, Nobili V .Vaccine, 2011, 29, 4654
http://www.ncbi.nlm.nih.gov/pubmed/21596082

21. Adolescent Premature Ovarian Insufficiency Following Human Papillomavirus Vaccination A Case Series Seen in General Practice. Little DT, Ward HRG. Journal of Investigative Medicine High Impact Case Reports, 2014, 2(4), 1. https://www.ncbi.nlm.nih.gov/pubmed/26425627

22. Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine. Anaya JM, Reyes B, Perdomo-Arciniegas AM, Camacho-Rodríguez B, Rojas-Villarraga A. Clin Exp Rheumatol, 2015, 33(4), 545 http://www.ncbi.nlm.nih.gov/pubmed/25962455

23. Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report. Yonee C, Toyoshima M, Maegaki Y, Kodama Y, Hayami H, Takahashi Y, Kusunoki S, Uchibori A, Chiba A, Kawano Y. Neuropediatrics, 2013, 44(5), 265.http://www.ncbi.nlm.nih.gov/pubmed/23378179

24. Death after Quadrivalent Human Papillomavirus (HPV) Vaccination: Causal or Coincidental?. Lucija Tomljenovic, Christopher A Shawhttp://dx.doi.org/10.4172/2167-7689.S12-001

25. A catastrophic failure. Wehbe Ehttp://dx.doi.org/10.1016/j.amjmed.2010.09.020

26. Postural tachycardia syndrome after vaccination with Gardasil. S. Blitshteyn European Journal of Neurology, 2010, 17, 7, 52http://dx.doi.org/10.1111/j.1468-1331.2010.03021.x

27. Orthostatic intolerance and postural tachycardia syndrome as suspected adverse effects of vaccination against human papilloma virus. Louise S. Brinth, Kirsten Pors, Ann C. Theibel, Jesper Mehlsen. Vaccine, 2015, 33, 22, 2602-2605 https://www.ncbi.nlm.nih.gov/pubmed/25882168

28. Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature. Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi. Immunol Res (2016).http://link.springer.com/article/10.1007/s12026-016-8820-z

29. Vaccinations and secondary immune thrombocytopenia with antiphospholipid antibodies by human papillomavirus vaccine. Mojca Bizjak , Or Bruck , Darja Kanduc , Sonja Praprotnik , Yehuda Shoenfeld. Seminars in Hematology. Volume 53, Supplement 1, 2016, S48–S50
https://www.ncbi.nlm.nih.gov/pubmed/27312165

30. Pancreatitis after human papillomavirus vaccination: a matter of molecular mimicry. Mojca Bizjak, Or Bruck, Sonja Praprotnik, Shani Dahan, Yehuda Shoenfeld. Immunol Res. 2016.http://link.springer.com/article/10.1007%2Fs12026-016-8823-9

31. Pancreatitis following human papillomavirus vaccination. Amitabha Das, David Chang, Andrew V Biankin and Neil D Merrett. Medical Journal of Australia. 189, 3, 2008. https://www.ncbi.nlm.nih.gov/pubmed/18673112
https://www.ncbi.nlm.nih.gov/pubmed/18673112

32. HPV vaccination syndrome. A questionnaire-based study. Martínez-Lavín M, Martínez-Martínez LA, Reyes-Loyola P. Clin Rheumatol. 2015 Nov;34(11):1981-3. doi: 10.1007/s10067-015-3070-3. Epub 2015 Sep 10.https://www.ncbi.nlm.nih.gov/pubmed/26354426

33. Hypothesis: Human papillomavirus vaccination syndrome--small fiber neuropathy and dysautonomia could be its underlying pathogenesis. Martínez-Lavín M. Clin Rheumatol. 2015 Jul;34(7):1165-9. doi: 10.1007/s10067-015-2969-z. Epub 2015 May 20. Review.
https://www.ncbi.nlm.nih.gov/pubmed/25990003

34. Small Fiber Neuropathy Following Vaccination. Kafaie J, Kim M, Krause E. J Clin Neuromuscul Dis. 2016 Sep;18(1):37-40.https://www.ncbi.nlm.nih.gov/pubmed/27552388

35. Postural tachycardia syndrome (POTS) with anti-NMDA receptor antibodies after human papillomavirus vaccination. Blitshteyn S, Brook J. Immunol Res. 2016 Aug 25
https://www.ncbi.nlm.nih.gov/pubmed/27561785

36. Involvement of chronic epipharyngitis in autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA). Hotta O, Tanaka A, Torigoe A, Imai K, Ieiri N; Japanese Focal Inflammation Research Group. Immunol Res. 2016 Sep 3. https://www.ncbi.nlm.nih.gov/pubmed/27592233

37. A link between human papilloma virus vaccination and primary ovarian insufficiency: current analysis. Gruber N, Shoenfeld Y. Curr Opin Obstet Gynecol. 2015 Aug;27(4):265-70. Review.
http://www.ncbi.nlm.nih.gov/pubmed/26125978

38. Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil Inbar R, Weiss R, Tomljenovic L, Arango MT, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. Immunol Res. 2016 Jul 16.
http://www.ncbi.nlm.nih.gov/pubmed/27421722

39. Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report. Yonee C, Toyoshima M, Maegaki Y, Kodama Y, Hayami H, Takahashi Y, Kusunoki S, Uchibori A, Chiba A, Kawano Y. Neuropediatrics. 2013 Oct;44(5):265-7.http://www.ncbi.nlm.nih.gov/pubmed/23378179

40. Development of unilateral cervical and supraclavicular lymphadenopathy after human papilloma virus vaccination. Studdiford J, Lamb K, Horvath K, Altshuler M, Stonehouse A. Pharmacotherapy. 2008 Sep;28(9):1194-7. https://www.ncbi.nlm.nih.gov/pubmed/18752390

41. The quadrivalent human papillomavirus vaccine: erythema multiforme and cutaneous side effects after administration | 2010 Pérez-Carmona L1, Aguayo-Leiva I, González-García C, Jaén-Olasolo P. Dermatology. 2010;221(3):197-200. http://www.karger.com/Article/Abstract/319852

42. Systemic lupus erythematosus following HPV immunization or infection? 2012 Soldevilla HF. Briones SF. Navarra SV. Lupus. 2012 Feb;21(2):158-61. https://www.ncbi.nlm.nih.gov/pubmed/22235047

43. Lack of effects on fertility and developemental toxicity of a quadrivalent HPV vaccine in Sprague-Dawley rats. Birth Defects. Wise LD, Wolf JJ, Kaplanski CV, Pauley CJ, Ledwith BJ. Birth Defects Res B Dev Reprod Toxicol. 2008 Dec;83(6):561-72.https://www.ncbi.nlm.nih.gov/pubmed/19025783

44. Evaluation of the intramuscular administration of CervarixTM vaccine on fertility, pre- and post-natal development in rats. Segal L, Wilby OK, Willoughby CR, Veenstra S, Deschamps M. Reprod Toxicol. 2011 Jan;31(1):111-20. https://www.ncbi.nlm.nih.gov/pubmed/20851759

45. New concerns about the human Papillomavirus Vaccine from American College of Pediatricians.
“long-term ovarian function was not assessed in either the original rat safety studies or in the human vaccine trials.” https://www.acpeds.org/…/new-concerns-about-the-human-papil…

46. Murine hypothalamic destruction with vascular cell apoptosis subsequent to combined administration of human papilloma virus vaccine and pertussis toxin. Aratani S. Fujita H. Kuroiwa Y. Usui C. Yokota S. Nakamura I. Nishioka K. Nakajimaa T. Sci Rep. 2016; 6: 36943.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105142/

47. Tubulointerstitial Nephritis and Uveitis Syndrome Associated With Human Papillomavirus Vaccine. Sawai T, Shimizu M, Sakai T, Yachie A. J Pediatr Ophthalmol Strabismus. 2016, 53(3), 190
https://www.ncbi.nlm.nih.gov/pubmed/27224955

48. Human papilloma virus vaccination and dysautonomia: Considerations for autoantibody evaluation and HLA typing. Hendrickson JE, Tormey CA. Vaccine. 2016, 34(38), 4468
https://www.ncbi.nlm.nih.gov/pubmed/27553747

49. Early cervical myelitis after human papilloma virus vaccination.
Mireya Fernández-Fournier, Díaz de Terán, Antonio Tallón Barranco, Inmaculada Puertas. Neurol Neuroimmunol Neuroinflamm. 2015, 2(1), e64.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303480/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204223/

50. Fibromyalgia-Like Illness in 2 Girls After Human Papillomavirus Vaccination. Martínez-Lavín M. J Clin Rheumatol. 2014, 20(7), 392.https://www.ncbi.nlm.nih.gov/pubmed/25275771

51. Can HPV immunisation cause ADEM? Two case reports and literature review. Pellegrino P, Carnovale C, Perrone V, Antoniazzi S, Pozzi M, Clementi E, Radice S. Mult Scler. 2014, 20(6), 762.https://www.ncbi.nlm.nih.gov/pubmed/23970503

52. Human Papilloma Virus Vaccine Associated Uveitis Holt HD, Hinkle DM, Falk NS, Fraunfelder FT, Fraunfelder FW. Curr Drug Saf. 2014, 9(1), 65.https://www.ncbi.nlm.nih.gov/pubmed/24191906

53. Autoimmune neuromyotonia following human papilloma virus vaccination. Chiara Cerami MD, Massimo Corbo MD, Giovanni Piccolo MD, Sandro Iannaccone MD. Muscle & Nerve. 2013, 47(3), 466.https://www.ncbi.nlm.nih.gov/pubmed/23364906

54. Kikuchi–Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis. Toru Watanabe, Hideki Hashidate, Yutaka Hirayama, Yasushi Iinuma. European Journal of Pediatrics. 2012, 171(9), 1409.http://link.springer.com/article/10.1007%2Fs00431-012-1729-1

55. Neuromyelitis optica following human papilloma virus vaccination. Menge T, Cree B, Saleh A, Waterboer T, Berthele A, Kalluri SR, Hemmer B, Aktas O, Hartung HP, Methner A, Kieseier BC. Neurology. 2012, 79(3), 285https://www.ncbi.nlm.nih.gov/pubmed/22722628

56. Linear IgA bullous dermatosis following human papillomavirus vaccination. Ikeya S, Urano S, Tokura Y. Eur J Dermatol. 2012, 22(6), 787https://www.ncbi.nlm.nih.gov/pubmed/23113902

57. Ampiginous choroiditis following quadrivalent human papilloma virus vaccine. Khalifa YM, Monahan PM, Acharya NR. Br J Ophthalmol. 2010, 94(1), 137. https://www.ncbi.nlm.nih.gov/pubmed/20385534

58. Quadrivalent Human Papillomavirus recombinant vaccine associated lipoatrophy. Ojaimi S, Buttery JP, Korman TM. Vaccine. 2009, 27(36), 4876.https://www.ncbi.nlm.nih.gov/pubmed/19555713

59. Multiple Evanescent White Dot Syndrome After Vaccination for Human Papilloma Virus and Meningococcus. Cohen SM. J Pediatr Ophthalmol Strabismus. 2009.
https://www.ncbi.nlm.nih.gov/pubmed/19645392

60. Opsoclonus myoclonus after human papilloma virus vaccine in a pediatric patient. McCarthy JE, Filiano J. Parkinsonism Relat Disord. 2009, 15(10), 792. https://www.ncbi.nlm.nih.gov/pubmed/19447066

61. Brachial plexus neuritis following HPV vaccination. Debeer P, De Munter P, Bruyninckx F, Devlieger R. Vaccine. 2008, 26(35), 4417.https://www.ncbi.nlm.nih.gov/pubmed/18602437


================================

Проучване коментира неуспехите на варицелната ваксина (жива) и немалкото боледуващи ваксинирани деца. Ваксиналните неуспехи са при боледуващите, при които не е допринесла за изграждане на антитела, но и при разболелите се въпреки изградените антитела. Както и нарастващата честота и тежест на заболяването във времето при ваксинирани заради намаляващ имунитет - такъв повишен риск се наблюдава около 4-5 години след ваксинацията.
До 24% от ваксинираните с първа доза не изграждат антитела към ваксиналните антигени, а понастоящем е неизвестно оптималното време за прилагане на втора доза варицелна ваксина.
Авторите обсъждат и неясната роля на антителата в защитата срещу варицела и специфичността на ваксината.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500254/

Същевременно е пренебрегната увеличената честота на херпес зостер в следваксиналната ера, както и ваксино-свързаните сериозни нежелани реакции/заболеваемост, също и заболеваемостта при възрастни. Масовата ваксинация срещу варицела не е осигурила дългосрочна защита от болестта.
https://www.ncbi.nlm.nih.gov/pubmed/22659447

Системен обзор показва не само случаи на тежко протичаща варицела с усложнения при ваксинирани, но и 6 смъртни случая при заболели ваксинирани.
https://www.ncbi.nlm.nih.gov/pubmed/28276305

Остър трансверзален миелит като усложнение от варицела при по-рано ваксиниран.
https://www.ncbi.nlm.nih.gov/pubmed/18410857

Случай на смърт на ваксинирано дете, причинен от самия ваксинален жив вирус.
https://www.ncbi.nlm.nih.gov/pubmed/23982221

Проблеми със зрението - оптичен неврит 1-3 седмици след ваксинацията.
https://www.ncbi.nlm.nih.gov/pubmed/25045807

Наблюдава се тежка инфекция от ваксиналния вирус при имунокомпрометирани. Дисеминирана варицела, дихателна недостатъчност и сепсис.
https://www.ncbi.nlm.nih.gov/pubmed/24257110
Изискващи хоспитализация кожни лезии от ваксиналния щам при пациент с трансплантирано сърце.
https://www.ncbi.nlm.nih.gov/pubmed/16847227

Живият ваксинален вирус на варицелата се предава от ваксинирани на контактни с тях.
https://www.ncbi.nlm.nih.gov/pubmed/9333170
https://www.ncbi.nlm.nih.gov/pubmed/18419392

12-месечно ваксинирано дете заразява бременната си майка с ваксиналния щам.
https://www.ncbi.nlm.nih.gov/pubmed/9255208

Самите ваксинирани развиват инфекция от ваксиналния вирус с проява на везикуларни (с мехурчета) обриви в период около 15-42 дни след ваксинацията и съответно я предават на контактни с тях.
https://www.ncbi.nlm.nih.gov/pubmed/18419392

Интересен факт е, че през 80-те години е имало многобройни възражения за провеждането на клинични изпитвания на ваксината при левкемични и здрави деца и възрастни, но въпреки това са извършени и приключват през 1995 г., а ваксината не се оказва толкова ефикасна, колкото се предвижда от изпитванията (каква "изненада" ;)).
Gershon A, Takahashi M, Seward J. Live attenuated varicella vaccine. In: Plotkin S, Orenstein W, Offit P, editors. Vaccines. Philadelphia: WB Saunders; 2008. pp. 915–958.